The minimally invasive Endo-Bentall procedure for the treatment of aortic root pathologies was the focus of a recent roundtable discussion at CX Aortic Live 2024 (7–8 October, Vienna, Austria). After agreeing on a precise definition for this “last frontier” in cardiovascular interventions—as described by discussion chair and course co-director Tilo Kölbel (University of Hamburg, Hamburg, Germany)—Mehrdad Ghoreishi (Miami, USA) and CX Aortic Live 2024 executive board members Michael Borger (Leipzig, Germany) and Davide Pacini (Bologna, Italy) pondered the future of this technique and underscored the importance of collaboration between specialties to ensure the best patient outcomes.